The higher mortality risk among class III and IV patients with an unstable course provides impetus for a revised CCSA definition incorporating this information.”
“Bacterial infections are the most frequent cause of hospitalization in elderly patients. In the early eighties, the advantages of Outpatient Parenteral Antibiotic Therapy (OPAT)were identified in the United States, and suitable therapeutic programs were established. In order to understand the GSK2879552 cost different ways of managing OPAT, a National OPAT Registry was set up in 2003 in Italy. This study analyzes data concerning bacterial infections in 176 elderly patients including
demographics, therapeutic management, clinical response, and side-effects. Bone and joint infections (48.9%) and skin and soft tissue infections (27.8%) were the most common infections
treated with OPAT. Teicoplanin (28.9%) and ceftriaxone (22.1%) were the top two antibiotics chosen. OPAT was mainly performed at a hospital infusion center (52.8%). The clinical success rate was high and side-effects were low (12.6% of cases). SU5402 ic50 Management of bacterial infections in the elderly with an outpatient program is effective and safe.”
“BACKGROUND: Plasma levels of the inflammatory biomarker C-reactive protein (CRP) predict cardiovascular risk and may represent a target for treating and/or monitoring risk-reduction strategies. The
effect of angiotensin-converting enzyme inhibitors
on CRP levels has not been adequately studied.
METHODS: A total of 264 men and women, with CRP levels of 2 mg/L or greater and no history of cardiovascular disease, were enrolled in a 12-week randomized, double-blind, placebo-controlled study. Participants
were randomly assigned to receive 10 mg/day of ramipril (n=132) or placebo
(n=132) for 12 weeks. The main outcome measure was the change in CRP levels from baseline to 12 weeks in the ramipril- versus placebotreated
RESULTS: The mean (+/- SD) age was 53 +/- 9 years (60% men). Baseline
demographics were similar between the volunteers allocated 4SC-202 to receive
either placebo or ramipril. The geometric mean CRP at baseline was
3.84 mg/L (95% CI 3.62 mg/L to 4.06 mg/L). The percentage change in
geometric mean CRP values over 12 weeks was -13.2% (95% CI -22.3% to -3.2% ) in the placebo group compared with -21% (95% CI – 29.9% to -11.2%) in the ramipril group (P nonsignificant), indicating no significant reduction in the primary end point of the trial.
CONCLUSIONS: A 12-week ramipril treatment protocol for healthy
middle-aged volunteers did not lower CRP levels compared with placebo.
However, because of the inherent variability of CRP levels, a much larger study is required to exclude a small treatment effect.”
“The influence of age and sex on chemotherapy-related toxicity was evaluated in children and adults with non metastatic osteosarcoma.