Pilot trials using TCR-engineered cells against melanoma-associated antigens MART-1 and gp100 and
the cancer-testis antigen NY-ESO-1 have shown clinical responses in patients with melanoma. CAR cells directed against melanoma have been tested only in preclinical models; however, CAR cells targeting other histologies such as lymphoma have elicited antitumor responses in patients.
Conclusions: An example of state-of-the-art personalized medicine, ACT is a potentially curative therapy for patients with metastatic melanoma. Ongoing trials aiming to simplify the Fer-1 mouse regimens may allow a broader range of patients to be treated and enable ACT to be offered by academic cancer centers.”
“Massive hematocolpos resulting from an imperforate hymen is quite a rare cause of acute urinary retention, in an adolescent girl admitted to the emergency department.
A 12-year-old girl suffering from severe inguinal pain and dysuria together with difficulty in urination for about 1 month was admitted to the emergency department for acute urinary retention. On gynecological examination, imperforate hymen was observed to be the cause of the urinary difficulty. Pelvic magnetic resonance imaging revealed a dilated vagina exerting pressure on the bladder outlet suggestive of hematocolpos. Cruciate hymenotomy was performed. The postoperative period and three follow-up visits of the patient
up to the 6th month were learn more uneventful.
The diagnosis of imperforate hymen can be missed if a genital examination is not performed in adolescent girls presenting to emergency departments
with urinary difficulty. The purpose of this paper is to increase awareness among emergency physicians about the probability of imperforate hymen while examining adolescent girls with urinary retention and intermittent lower abdominal pain.”
“The magnetic properties of single crystal Fe1-xGax thin films deposited on ZnSe/GaAs(001) and MgO(001) substrates Fludarabine by molecular beam epitaxy were investigated by vibrating sample magnetometry and angle dependent ferromagnetic resonance. Depositions on the ZnSe buffer layer feature a strong uniaxial anisotropy that scales with the thin film magnetostriction of the samples, while depositions on MgO(001) substrates result in a purely cubic anisotropy whose cubic anisotropy constant, K-1, switches sign at a lower Ga concentration than is seen in bulk. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3367971]“
“A Bisphenol-A based polycarbonate was stabilized by a new polymer stabilizer named di(p-butoxyphenyl)cyclohexylphosphine oxide. The stabilizer was mixed with the polymer in methylene chloride solution. Later, the solution was vaporized and the stabilized polymer was dried. Specimens were cut and heat treated at different temperature and durations.