Int J Cancer 1999, 80: 791–795.CrossRefPubMed 12. Sawai

selleck screening library H, Funahashi H, Yamamoto M, Okada Y, Hayakawa T, Tanaka M, Takeyama H, Manabe T: Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancer. Oncology 2003, 65: 167–173.CrossRefPubMed 13. Hosotani R, Kawaguchi M, Masui T, Koshiba T, Ida J, Fujimoto K, Wada M, Doi R, Imamura M: Expression of integrin alphaVbeta3 in pancreatic carcinoma: relation to MMP-2 activation and lymph node metastasis. Pancreas 2002, 25: e30–5.CrossRefPubMed 14. Pignatelli M, Hanby AM, Stamp GW: Low expression of beta 1, alpha 2 and alpha 3 subunits of VLA integrins in malignant mammary tumours. J Pathol 1991, 165: 25–32.CrossRefPubMed 15.

Zutter MM, Mazoujian G, Santoro SA: Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast. Am J Pathol 1990, 137: 863–870.PubMed 16. Brakebusch C, Wennerberg K, Krell HW, Weidle UH, Sallmyr A, Johansson S, Fassler R: Beta1 integrin promotes but is not buy PD0332991 essential for metastasis of ras-myc transformed fibroblasts. Oncogene 1999, 18: 3852–3861.CrossRefPubMed 17. Fidler IJ, Kripke ML: Metastasis results from preexisting variant cells within a malignant tumor. Science 1977, 197: 893–895.CrossRefPubMed 18. LDC000067 ic50 Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF, Simeone DM: Identification of Pancreatic Cancer Stem Cells. Can Res 2007, 67: 1030–1037.CrossRef 19. Heenan M, O’Driscoll L, Cleary I,

Connolly L, Clynes M: Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance. Int J Cancer 1998, 71: 907–915.CrossRef 20. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN: A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 1987, 47: 3239–3245.PubMed 21. Carter WG, Wayner EA, Bouchard TS, Kaur P: The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells. J Cell Biol 1990, 110: 1387–1404.CrossRefPubMed 22. Carey BM, Dooley M, Weedle R, Clynes M: Production of autostimulatory growth factors by the human carcinoma line, RPMI 2650. In Dipeptidyl peptidase Vitro Cell Dev Biol 1993, 29A: 153–160.CrossRefPubMed 23. Grzesiak JJ, Bouvet M: The alpha2beta1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines. Br J Cancer 2006, 94: 1311–1319.CrossRefPubMed 24. DiMagno EP, Reber HA, Tempero MA: AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. Gastroenterolgy 1999, 117: 1464–1484.CrossRef 25. Tryggvason K, Hoyhtya M, Salo T: Proteolytic degradation of extracellular matrix in tumor invasion. Biochim Biophys Acta 1987, 907: 191–217.PubMed 26.