In patients with platinum-resistant and even platinum-refractory disease the response rate (of IWP-2 ic50 PARP inhibitor, olaparib) was of 41.7% and 15.4%, respectively . Olaparib (AZD2281) was tested in BRCA-mutated patients with ovarian, primary peritoneal, and fallopian tube cancer. In the study, 20 patients (40%) responded to the therapy. Currently, randomized trials of olaparib and other PARP inhibitors in patients with ovarian cancer are underway. Conclusion Maximal surgical cytoreduction followed by systemic taxane and platinum-based chemotherapy is the standard treatment for patients with ovarian
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