When transfer on a stiff substrate these cells retain their capacity to adhere, to spread and to enter a novel mitotic cycle. A similar effect is Observed on soft substrates

(50 kPa) without need of histone deacetylase inhibition. These new results suggest that on soft substrates cells might enter in a quiescence state. Cell quiescence may thus be triggered by the Young modulus of a substrate, a major result for strategies focusing on the design of scaffold in tissue engineering. (C) 2014 Elsevier Ltd. All rights reserved.”
“Introduction: Social support can facilitate compliance or adherence to recommended treatment regimens, especially for chronic disease management. There is little data from Africa SB273005 in vivo on the role of social support in the management of chronic disease. Objective: The current study investigated the relationship between social support for treatment compliance among hypertensive subjects in a poor urban community in southwest Nigeria. A second objective was identifying the correlates of social support in the study sample. Methods: The study was a community-based, cross-sectional and descriptive study of 440 community residents

(mean age 60 years, 65.2% women) from Idikan community, Ibadan, Nigeria who had hypertension. Results: Most subjects (similar to 93%) reported receiving some social support from family members and approximately 55% reported receiving social support from friends. Social support from friends (p smaller than 0.0001) but not from family (p = 0.162) was significantly associated with good compliance with treatment for hypertension. Apoptosis inhibitor Factors associated with receiving significant support SRT2104 cost from both family and friends included

marital status and religion, while age and educational level were associated with receiving significant support from family members only. Gender was not significantly associated with receiving social support. Conclusion: We concluded that social support is strongly associated with hypertension treatment compliance in this community in south-west Nigeria. These findings suggest a need for exploring the promotion of social support as a useful tool in chronic disease treatment programmes.”
“The outcomes of complex major surgery in the elderly are being scrutinized because of the demands on surgical services by an aging population and the concern whether such endeavors are justified. Pancreatoduodenectomy (PD) for pancreatic adenocarcinoma presents special challenges because of the high morbidity of the procedure, dismal prognosis of the disease, and the increasing incidence of pancreatic cancer with age.\n\nAll patients who underwent PD for pancreatic adenocarcinoma from 1981 to 2007 were analyzed for perioperative outcomes, tumor-related parameters, use of adjuvant therapy, and long-term survival.