We illustrate the effect of geometry on flushing by examining a series of tanks with increasing geometrical

complexity from a 2×2, 3×3 to 5×4 tank. To build up a physical picture of the dynamics, we first analyse the simplest configuration – a four connected compartment arrangement with one inlet and two outlets, shown in Fig. 4(a). In order to simplify the analysis, we assume that the four compartments have the same shape and dimensions, and all the four holes between neighbouring compartments are the same thin-wall circular orifices in size, height and resistance. Similarly for the 3×3 case (see Fig. 4(b)), all the circular orifices between neighbouring compartments are geometrically congruent and same in height. The solution is determined by four mass conservation equations by setting m  =n  =2 in Appendix A: equation(11) f11,12+f11,21=Q,f11,12=f12,22,f11,21=f21,22+Q21,out,f12,22+f21,22=Q22,out;and AZD0530 price four empirical closures for the pressure drop: equation(12) p11−p12=ξ11,12ρ|f11,12|f11,12A11,122,p21−p22=ξ21,22ρ|f21,22|f21,22A21,222,p11−p21=ξ11,21ρ|f11,21|f11,21A11,212,p12−p22=ξ12,22ρ|f12,22|f12,22A12,222.In Dapagliflozin datasheet this example, we consider the influence of outlet arrangement on flushing where the geometry of the lightening holes is the same. Here ξ11,12=ξ21,22=ξ11,21=ξ12,22ξ11,12=ξ21,22=ξ11,21=ξ12,22 and A11,12=A21,22=A11,21=A12,22A11,12=A21,22=A11,21=A12,22. When only the far outlet is

open (Q21,out=0Q21,out=0, p22=0p22=0), the solution to the equation array is equation(13) f11,12=f11,21=f12,22=f21,22=Q2,Q22,out=Q;when only the near outlet is open (Q22,out=0Q22,out=0, p21=0p21=0), after manipulation, the solution is equation(14) f11,12=f12,22=(3−1)Q2,f21,22=(1−3)Q2,f11,21=(3−3)Q2,Q21,out=Q;when both outlets are open (p21=p22=0)(p21=p22=0), the fluxes between the compartments are equation(15) f11,12=f12,22=Q22,out=(2−1)Q,f21,22=0,f11,21=Q21,out=(2−2)Q. The flushed fraction in each compartment evolves according to the following: equation(16) dC11dT=VV11(1−C11),dC12dT=VV12(f11,12QC11−f12,22QC12),dC21dT=VV21(f11,21QC11−f21,22Q(H(f21,22)C21+H(−f21,22)C22)−Q21,outQC21),dC22dT=VV22(f12,22QC12+f21,22Q(H(f21,22)C21+H(−f21,22)C22)−Q22,outQC22),and

Bcl-w satisfies the initial condition C[i][j]|T=0=0.C[i][j]|T=0=0.The Heaviside function (where H(X)=1H(X)=1 for X≥0X≥0 and H(X)=0H(X)=0 for X<0X<0) is needed to prevent flow in the wrong direction. The system of coupled linear differential equations can be solved analytically and the solution for V[i][j]/V=1/4V[i][j]/V=1/4 is given in Appendix B. The curves in Fig. 5 show the predicted flushed fraction variation in each compartment of the 2×2 tank for the three cases considered.