Three patients had liver biopsy because of abnormal liver function tests. Correlations with Ishak scores were higher with ARFI values (Pearson r: ARFI L 0.63; ARFI R 0.68; TE 0.62 and with METAVIR scores (ARFI L r=0.63; ARFI R 0.33; TE 0.57). Correlation

with serum aminotransferase/platelets showed a statistical significance for ARFI (ARFI L r=0.67; TE 0.4). In contrast, there were weak correlations with necroinflammatory score (ARFI r=0.23; BGB324 price TE 0.26) and steatosis score (ARFI r=0.24; TE 0.32). Diagnostically, there was a significantly better accuracy of ARFI of the left lobe (ARFI L), compared to ARFI measured in the right lobe (ARFI R) and TE (AUC ARFIL 0.90; ARFI R 0.74; TE 0.73). Conclusion: ARFI of the left lobe performs

diagnostically better than TE and correlates well with histological scores of liver fibrosis. As with previous reports, we showed a interlobe variations of liver stiffness. Further validation of our findings is warranted. Disclosures: Yasmin Pasha – Grant/Research Support: Merz Pharmaceuticals GmbH, Frankfurt, Germany The following people have nothing to disclose: Sebastiana Atzori, Nimzing Ladep, Heather Marcinkowski, Vanessa Tooley, Simon D. Taylom-Robinson Background: RO4929097 18F-FDG PET-CT(18F-fiuorodeoxygIucose positron emission tomography-computed tomography) has been widely used in many kinds of malignant tumors. However, the efficacy of 18F-FDG PET-CT in hepatocellular carcinoma(HCC) is still controversy. We aimed to evaluate the usefulness of 18F-FDG PET-CT in staging and treatment of HCC. Methods:

We analyzed the HCC patients PAK6 retrospectively who took 18F-FDG PETCT examination from January 2008 to December 2012. We compared the stage and treatment between before and after 18F-FDG PET-CT to know the efficacy on HCC. We reviewed the medical record, biopsy result, follow-up CT and follow-up data to know the confirmation of the extrahepatic metastasis which was suspected in 18F-FDG PET-CT. Results: Total 160 HCC patients were analyzed.27 patients (16.9%) of them were suspected as extrahepatic metastasis on 18F-FDG PET-CT. High FDG uptake on lung was observed on 18 patients.13 patients of them were already suspected as hematogenous lung metastasis in liver CT.3 patients of them were diagnosed as benign lesion on chest CT and biopsy. Lung masses of 2 patients were detected on only 18F-FDG PET-CT, but there was no changes of staging. High FDG uptake of extraabdominal L/N was found on 2 patients (inguinal and supraclavicular L/N). They were diagnosed as benign L/N enlargement. High FDG uptake on bone was found at 4 patients.3 patients of them showed bone metastasis in liver CT and 1 patient who had metastasis to mandible diagnosed as both adrenal metastasis without staging change.1 patient showed high uptake on prostate and confirmed as benign nodule on biopsy.1 patient with abdominal muscle metastasis was detected on both liver CT and 18F-FDG PET-CT.