This software also includes ECG monitoring in order to monitor vessel wall motility during cardiac cycle (systolic and diastolic changes). At the end of the measurement, vessel motility parameters appear in the form of report – arterial stiffness was taken as measure of vessel wall function (blood pressure logarithm/change of vessel wall diameter). Statistical analysis of different groups of subjects was performed Quizartinib cost by Student’s t test (statistical significance was obtained at p < 0.05 value). Variation

coefficient was calculated for BHI values as a measure of data dispersion for each group. MBFV and BHI values were compared using Pearson’s linear correlation coefficient. The aim of this study was to evaluate BHI and AS in healthy population in correlation with diabetic patients with good and poor regulated Sotrastaurin solubility dmso serum glucose levels,

groups were aged standardized in order to minimize impact of age as risk factor for vascular aging. Data did not show any statistically significant differences in BHI and AS values between the left and right side of Willis circle as well as for common carotid artery, and this distinction was excluded from the model. There was no difference in mean BHI and AS values between males and females therefore we presented pooled data – mean BHI and AS values and SD for each group (Table 1). In healthy volunteers all values remain in range between 1.03 and 1.65 – there is decreasing trend in BHI values and increasing trend of AS values depending on glucose control (p < 0.05) ( Fig. 1). There was

increase in AS in correlation with glucose levels (r = 1.42, p < 0.05), there was no statistically significant differences between left and right side as well as the sex differences in evaluated model, therefore we presented pooled data. There was statistically significant negative correlation between BHI and serum glucose levels (r = −0.14, p < 0.05) in all groups, especially in group of diabetic patients with poorly controlled glucose levels. Results Bortezomib of the previous studies have shown that there is no statistically significant differences between BHI in anterior (anterior – ACA and middle cerebral artery – MCA) and posterior circulation (posterior – PCA, vertebral – VA and basilar – BA arteries) in individuals without atherosclerotic plaques on the main head and neck vessels, therefore we measured BHI in MCA. Also, in our previous studies we have standardized BHI measurement method and we have shown that BHI is linear index, therefore there is no difference between short (<27 s) and long (>27 s) measurement times [12], [13] and [14].