This economic relationship resulted in the eventual domestication of Rangifer. The hypothesis of whether domestication was achieved as early as the Late Palaeolithic, and whether this required the use of domesticated dogs (Canis familiaris) as hunting, herding or transport aids, is tested via a comparative analysis using material culture-based phylogenies and ecological datasets in relation to demographic/genetic proxies. Only weak evidence for sustained niche construction

behaviours by prehistoric hunter-gatherer in southern Scandinavia is found, but this study nonetheless provides interesting insights into the likely processes of dog and reindeer domestication, and into processes of adaptation in Late Glacial foragers.”
“Background. Selleckchem ABT-263 a 31-year-old woman with an 11-year history of poorly controlled type 1 diabetes mellitus was admitted 3-MA with severe vomiting and ketoacidosis. the patient had been admitted to hospital on 14 occasions in the past 3 years for diabetic ketoacidosis precipitated by intractable vomiting, and she had been diagnosed with gastroparesis 2 years previously.

Investigations. assessment of the patient’s response to standard treatments for diabetic gastroparesis. these approaches involved tight glycemic control that included subcutaneous

insulin infusion via a pump, correction of electrolyte disturbances, use of standard antiemetic and promotility agents, somatostatin-analog treatment, intrapyloric injection

of botulinum toxin, and insertion of a percutaneous jejunal feeding tube.

Diagnosis. severe diabetic gastroparesis refractory to standard treatments.

Management. the neurokinin-receptor antagonist aprepitant was started and her vomiting stopped within 24 h. this treatment was successfully continued for 4 months until a gastric electrical stimulation device was inserted, which enabled aprepitant treatment to be withdrawn and the percutaneous jejunostomy feeding tube to be removed. this successful treatment led to a substantial improvement in the patient’s quality of life and overall glycemic control.”
“Stress migration (SM) reliability data have been treated qualitatively to define pass or fail criteria in the past. However, realistic quantitative SM analysis and lifetime estimates for CAL-101 PI3K/Akt/mTOR inhibitor products were not available due to lack of a suitable SM model. In this paper, we establish a comprehensive SM model for quantitative stress-induced-voiding (SIV) risk analysis for 32 nm technology and beyond. It was found that the SIV risk is dependent on both stress temperatures and geometric structural line widths as driving forces. Based on the new SM model, the SM lifetime can be estimated from measurable SM data and accelerated SM test methods can be designed to meet the qualification criteria. (C) 2011 American Institute of Physics. [doi:10.1063/1.