These patients also completed the Medical Research Council (MRC) dyspnoea scale, the Leicester Cough Questionnaire (LCQ), and the hospital anxiety and depression scale; performed 6-min walk tests and GDC-0973 datasheet pulmonary function tests; and provided samples for arterial blood gas analysis.
Results:
There was a very strong correlation between the CAT score and the SGRQ total score (r = 0.93, P < 0.0001). The CAT score was also significantly correlated with the SGRQ symptoms score (r = 0.74, P < 0.0001), the SGRQ activity score (r = 0.87, P < 0.0001) and the SGRQ impact score (r = 0.89, P < 0.0001). Stepwise multiple regression analysis demonstrated that the MRC and LCQ scores contributed most to both the CAT score and the SGRQ total score.
Conclusions: The CAT is a short and simple questionnaire that shows good and valid measurement properties for assessing the health status of
patients with ILD.”
“SETTING: The Philippines, one of the high tuberculosis (TB) burden countries.
OBJECTIVE: 5-Fluoracil research buy To determine the prevalence of anti-tuberculosis drug resistance in the first nationwide systematic survey.
DESIGN: A population-proportionate cluster sampling method was employed. Smear-positive pulmonary TB patients aged >= 15 years were eligible. Drug susceptibility testing was performed against four first-line drugs, i.e., isoniazid, rifampicin, ethambutol and streptomycin.
RESULTS: A total of 1091 patients were enrolled during a 17-month period starting In June 2003, of whom 935 (85.7%) were new cases and 121. (11.1%) previously treated cases. Resistance to any of the four drugs was seen in 20.4% (95%CI 18.1-22.9) of new cases, CA3 purchase in 38.8% (95%CI 27.8-51.1) of previously treated cases and in 22.1% (19.7-24.9) of both new and previously treated cases combined. The prevalence of multidrug resistance was respectively 3.8% (95%CI 2.6-5.5),20.9% (95%CI 13.0-32.0) and 5.7% (95%CI 4.3-7.5).
The prevalence of drug resistance among new cases was higher than the global average and it was widespread throughout the country.
CONCLUSION: Confronted with the high prevalence of drug resistance, current efforts by the government to ensure better quality treatment programme should be strengthened.”
“Background: We have earlier reported that follicle stimulating hormone (FSH) modulates ovarian stem cells which include pluripotent, very small embryonic-like stem cells (VSELs) and their immediate descendants ‘progenitors’ termed ovarian germ stem cells (OGSCs), lodged in adult mammalian ovarian surface epithelium (OSE). FSH may exert pleiotropic actions through its alternatively spliced receptor isoforms. Four isoforms of FSH receptors (FSHR) are reported in literature of which FSH-R1 and FSH-R3 have biological activity. Present study was undertaken to identify FSHR isoforms mediating FSH action on ovarian stem cells, using sheep OSE cells culture as the study model.