Since CPA and IFO are widely used anticancer drugs, their efficacy is limited not only by their toxicity but also due to occurring resistance. This resistance seems to be a result of changes of expression and activity hypoxia-inducible factor pathway of enzymes such as CYP and aldehyde dehydrogenase (ALDH) and increase of intracellular

levels of glutathione (GSH) and glutathione S-transferase (GST). At present a few methods of overcoming this resistance are being examined including the use of metabolism modulators, antisense oligonucleotides selectively inhibiting gene expression, and introducing genes of some CYP isoenzymes to a cancer tissue.”
“Objective: Implanting active middle ear implants (AMEI) at the round window has become a standard procedure to restore hearing for patients with moderate inner ear or mixed hearing loss. The round window (RW)-Coupler was developed as an

alternative coupling aid to fit smaller RW diameters and require less drilling in the RW niche. The question arises whether using the RW-Coupler is useful and a safe procedure compared with the nonuse of the RW-Coupler

Materials and Methods: Forty-nine German-speaking patients were implanted with either a RW-Coupler attached to an AMEI floating Compound Library cell line mass transducer (FMT) or without coupler. They were evaluated preoperatively and postoperatively for bone and air conduction thresholds with and without the implant, as well as speech perception tests.

Results: Bone conduction thresholds remained stable preoperatively and postoperatively. 17DMAG mw The patient’s functional gain was slightly better with the RW-Coupler. Focusing on the

average speech perception performances, both groups presented an improvement of speech perception above 80% at 65 dB HL.

Conclusion: RW-Coupler-Vibroplasty was found to be a safe procedure, which produced good results in this group of patients with mixed hearing loss.”
“Ovarian hyperstimulation syndrome (OHSS) is in iatrogenic complication of ovulation induction, which may seriously affect the patient’s health, with 0.1-2.0% of the patients developing severe forms of the syndrome. OHSS signs and symptoms are direct consequences of fluid shift from capillaries to the third space due to increased vascular permeability. The mechanisms of OHSS pathophysiology remain unknown but evidence obtained in animal models prove that vascular endothelial growth factor (VEGF) is directly involved and the inhibition of the VEGF system could prevent OHSS from occurring. Dopamine agonists impede the phosphorylation of the VEGF receptor 2 and reduce the incidence and severity of OHSS with a safe clinical profile. As far as is known, this is the first pathophysiological approach for treatment and prevention of OHSS.”
“Objective: To evaluate platelet function in mothers and fetuses/neonates exposed to magnesium sulfate intrapartum.