Here, we report that IDR E804 inhibited endothelial cell proliferation, migration and tube formation in vitro assays working with human umbilical vein endothelial cells Moreover, IDR E804 inhibited tumor growth through a reduction in CD31 and Ki 67 positive cells and enhanced apoptosis during the allograft colon tumor model. Moreover, mechanistically, IDR E804 right buy Entinostat Celecoxib inhibits VEGFR 2 kinase exercise in vitro and leads to a re duction of phosphorylation of VEGFR 2, AKT and ERK in VEGF stimulated HUVECs. Our scientific studies suggest that IDR E804 is often a novel angiogenesis inhibitor and could possibly be a possible drug candidate for angiogenesis relevant disorders.