P. T., B. G., M. L., and J. J. are current employees of GSK Biologicals; M. L. and J. J. also have stock Bortezomib supplier ownership at GSK Biologicals. “
“Ciguatera fish poisoning is a travel-related illness characterized by a combination of gastrointestinal and neurological symptoms in persons who eat ciguatoxic seafood in endemic areas. In 2009, an outbreak of the disease on a

refrigerator vessel in the port of Hamburg was investigated. The ship’s crew fell ill after they ate fish from a catch in the Caribbean 2 weeks earlier. All 15 sailors on board were examined by port medical officers. Samples of blood and stool specimens were taken from symptomatic sailors. The frozen fish was secured for the prevention of further disease spreading and additional diagnostic tests. All but one sailor ate the fish. The intoxication resulted in gastrointestinal or neurological symptoms in all 14 sailors who consumed the

fish and persisted in varying degrees in 93% of sailors over at least 14 days. No fatality occurred, but two seamen were “unfit for duty” on the ship due to severity of symptoms. The diagnosis was supported by the fact selleck that all seafarers who consumed the same reef fish, experienced typical signs, symptoms, and time course consistent with ciguatera fish poisoning. The fish from the catch in the Caribbean was identified as Caranx sexfasciatus (Bigeye Trevally) and Cephalopholis miniata (Red Grouper). An experimental assay later confirmed presence of the ciguatoxin in the fish. Sailors are an occupational group at risk for ciguatera fish poisoning due to potentially unsafe food sources Meloxicam during international travel. Even if no fatality occurred, the disease affected

marine operations due to high attack rates and chronicity of symptoms. Medical doctors must be aware that ciguatera fish poisoning is a risk for seafarers traveling in tropical and subtropical areas. Stocking of food in affected ports from safe sources, adequate training of ship cooks, and informing sailors about the risk of fishing are needed to prevent disease occurrence in seafarers in international trade and traffic. Ciguatera fish poisoning is an illness characterized by a combination of gastrointestinal, neurological, and neuropsychiatric symptoms in people who eat seafood that contains the naturally occurring ciguatoxins. Most of the reported cases are related to the consumption of large reef fish in travelers to tropical and subtropical areas and to inhabitants of endemic areas. The global incidence of the disease was estimated to affect annually between 10,000 and 50,000 individuals; however, the accurate epidemiology is difficult to assess since reporting is a requirement in only a few countries.[1, 2] This article summarizes the investigation results in an outbreak on board a cargo ship under Bahamian flag that was docked in the Port of Hamburg in Germany for repair work.