Objective. To compare body length variation among adult curved and noncurved curveback female guppies.
Summary of Background Data. Tallness and/or abnormal anthropometric parameters have been correlated to idiopathic-type scoliosis (IS) in numerous studies. Heritable curvature in curveback has Staurosporine demonstrated
morphologic and developmental similarities to human IS. Because control of body length in the guppy is heritable and variable, we investigated whether length might also be correlated to curvature in the curveback population.
Methods. Component body lengths were measured from digital photographs for 321 (246 curved and 75 noncurved) females. Sources of experimental variation were omitted by only measuring 2-dimensional curves in mature females all from the same pedigree, and raised under controlled conditions of diet and environment. Body length was divided into 2 component parts (precaudal and caudal). Body lengths were tested statistically for correlation to curvature and curve magnitude.
Results. Although absolute length does not correlate to curvature, this survey of length in the curveback model reveals 2 important similarities to anthropometric studies of IS: that there are disproportionate body
lengths among females with curvature, and Selonsertib the suggestion of an underlying growth abnormality among curved individuals.
Conclusion. In order to better characterize the relationship between growth, length disproportion, and curvature in the guppy, further studies are warranted. However, this inquiry further supports the usefulness of curveback as a model for understanding the basic biology of idiopathic-type scoliosis and encourages study of growth-related factors.”
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“The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish final year medical students.