Int J Food Microbiol 2010, 144:42–50.PubMedCrossRef 44. Zenhom M, Hyder A, de Vrese M, Heller KJ, Roeder T, Schrezenmeir J: Prebiotic oligosaccharides reduce proinflammatory cytokines in intestinal Caco-2 cells via activation of PPARgamma and peptidoglycan recognition protein 3. J Nutr 2011, 141:971–977.PubMedCrossRef 45. Carr KE, Toner PG: Morphology of the Intestinal Mucosa. Pharmacology of Intestinal Permeation I. Handbook of Experimental Pharmacology Volume 70/1. Edited by: Csiiky ITZ. Berlin: Springer; 1984:1–50.CrossRef 46. Lepage P, Seksik P, Sutren M, de la Cochetière MF, Jian R, Marteau P, Doré J: Biodiversity

of the mucosa-associated microbiota is stable along the distal digestive tract in healthy individuals and patients with IBD. Inflamm Bowel Dis 2005, 11:473–480.PubMedCrossRef 47. Khan MT, Duncan SH, Stams AJ, van Dijl JM, Flint HJ, Harmsen Rigosertib datasheet HJ: The gut Selleck Selinexor anaerobe Faecalibacterium Dactolisib datasheet prausnitzii uses an extracellular electron shuttle to grow at oxic-anoxic interphases. ISME J 2012, 6:1578–1585.PubMedCentralPubMedCrossRef 48. Belenguer A, Duncan SH, Calder AG, Holtrop G, Louis P, Lobley GE, Flint HJ: Two routes of metabolic crossfeeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut.

Appl Environ Microbiol 2006, 72:3593–3599.PubMedCentralPubMedCrossRef 49. Falony G, Vlachou A, Verbrugghe K, Vuyst LD: Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol 2006, 72:7835–7841.PubMedCentralPubMedCrossRef 50. Louis P, Flint HJ: Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett 2009, 294:1–8.PubMedCrossRef 51. Pullan RD, Thomas G, Rhodes M: Thickness of adherent mucous gel on colonic mucosa in humans and its relevance to colitis. Gut 1994, 35:353–359.PubMedCentralPubMedCrossRef 52. Pignata S, Maggini L, Zarrilli R, Rea A, Acquaviva AM: The enterocyte-like differentiation of the Caco-2 tumor cell line strongly

correlates with responsiveness to cAMP and activation of kinase A pathway. Cell Growth Differ 1994, 5:967–973.PubMed 53. Fluent INC: Fluent 6 User Manual. New York: Fluent Inc.; 2006. 54. Ambati J, Canakis CS, Miller JW, Gragoudas ES, Edwards A, Weissgold DJ, Kim I, Delori FC, Adamis Anidulafungin (LY303366) AP: Diffusion of high molecular weight compounds through sclera. Invest Ophthalmol Vis Sci 2000, 41:1181–1185.PubMed 55. van den Abbeele P, Grootaert C, Possemiers S, Verstraete W, Verbeken K, van de Wiele T: In vitro model to study the modulation of the mucin-adhered bacterial community. Appl Microbiol Biotechnol 2009, 83:349–359.PubMedCrossRef 56. Blockhuys S, Vanhoecke B, Paelinck L, Bracke M, de Wagter C: Development of in vitro models for investigating spatially fractionated irradiation: physics and biological results. Phys Med Biol 2009, 54:1565–1578.