Conclusions. The results AZD2014 in vitro suggest that IQ, executive function and verbal learning deficits in schizophrenia may reflect a common abnormality of information processing in prefrontal cortex rather than specific impairments in different cognitive domains. Verbal memory retention impairments, however, may have a different aetiology.”
“Background About 15% of adults worldwide have a disability. These individuals are frequently reported to be at increased

risk of violence, yet quantitative syntheses of studies of this issue are scarce. We aimed to quantify violence against adults with disabilities.

Methods In this systematic review and meta-analysis, we searched 12 electronic databases to identify primary research studies published between Jan 1, 1990, and Aug 17, 2010, reporting prevalence estimates of violence against adults (aged mainly >= 18 years) with disabilities, or their risk of violence compared with non-disabled adults. We included only studies reporting violence occurring within the 12 months before the study. We assessed studies with six core quality criteria,

and pooled data for analysis.

Findings Of 10 663 references initially identified, 26 were eligible for inclusion, with data for 21 557 individuals with disabilities. 21 studies provided data suitable for meta-analysis of prevalence of violence, and ten for meta-analysis of risks of violence. Pooled prevalence of any (physical, sexual, or intimate partner) recent violence was 24.3% (95% CI 18.3-31.0) in people with mental illnesses, 6.1% (2.5-11.1)

in those with intellectual impairments, and 3.2% (2.5-4.1) in those with non-specific MX69 ic50 impairments. We identified substantial heterogeneity in most prevalence estimates (I-2 > 75%). We noted large uncertainty around pooled risk estimates. Pooled crude odds ratios for the risk of violence in disabled compared with non-disabled individuals were 1.50 (95% CI 1.09-2.05) for all studies combined, 1.31 (0.93-1.84) for people CYTH4 with non-specific impairments, 1.60 (1.05-2.45) for people with intellectual impairments, and 3.86 (0.91-16.43) for those with mental illnesses.

Interpretation Adults with disabilities are at a higher risk of violence than are non-disabled adults, and those with mental illnesses could be particularly vulnerable. However, available studies have methodological weaknesses and gaps exist in the types of disability and violence they address. Robust studies are absent for most regions of the world, particularly low-income and middle-income countries.”
“Background. There is increasing evidence that the frequently reported working memory impairments in schizophrenia might be partly due to in alteration in the functional connectivity between task-relevant areas. However, little is known about the functional connectivity patterns in schizophrenia patients during learning processes. In a previous study, Koch et al.