An early diagnosis and a prompt establishment of an adequate antibiotic treatment is needed for a successful recovery.”
“Background: It is
known that some patients with supraventricular tachycardia (SVT) could have increased troponin levels without coronary artery disease.
Objectives: To compare the cardiovascular P5091 ic50 risk of patients admitted with SVT with troponin T elevation (T+ patients) versus those without (T-patients), to determine if the rise in troponin levels could be predicted, and to identify the right approach in T+ patients. Methods: Retrospective database search of patients with SVT from 2002 to 2007 either with or without troponin T elevation at admission.
Results: Of the 73 study patients, there were 24 (32.9%) T+ patients and 49 (67.1%) T-patients. LY3039478 chemical structure All except 5 T+ patients underwent either a stress test/MIBI or a coronary angiogram. Two noninvasive tests were positive and only 1 patient needed an angiogram and percutaneous coronary intervention; none of the other angiograms triggered any further treatment. Of the 49 T-patients, 11 had a noninvasive stress test; none of these tests was positive or triggered any further treatment. Compared with that of T-patients, the maximum heart rate was significantly higher in T+ patients (190.8 versus 170.3
beats per minute, P = .008). A correlation was found between the maximal heart rate during SVT and the level of troponin elevation (r = 0.637, P = .001).
Conclusions: SVT could be associated with a troponin elevation without any severe coronary artery disease. In most patients, either conservative management or noninvasive stratification seems to be sufficient; an invasive strategy could then be reserved only for high-risk patients who tested positive. The only clinical variable correlated with the troponin rise was a higher maximal heart rate during the SVT episode.”
“Background: Oculocutaneous albinism (OCA) is a relatively common inherited disorder in all populations worldwide. The mutational spectra of OCA
are population-specific.
Objective: Based on our previous molecular epidemiological studies, we have implemented an optimized strategy for the genetic testing of Chinese OCA patients.
Methods: Genomic DNA was extracted from see more the blood samples of 52 clinically diagnosed OCA patients and 100 unaffected subjects. The amplified DNA segments were screened for mutations of TYR, OCA2, TYRP1, SLC45A2 and HPS1 by direct sequencing. To exclude the previously unidentified alleles (PUAs) from polymorphisms, samples from 100 unaffected controls were sequenced for the same regions of variations.
Results: Among the 52 OCA patients, 26(50.0%) were found mutations on TYR gene, 8(15.4%) on OCA2, 12 (23.1%) on SLC45A2, 2 (3.8%) on HPS1, and 4 (7.7%) patients uncharacterized. We identified 18 PUAs in these patients, 2 in TYR, 7 in OCA2, 8 in SLC45A2, and 1 in HPS1.