A 55-year-old man was scheduled for resection of an selleck chemicals oligoastrocytoma in his right frontal lobe. After smooth induction of general anesthesia, anesthesia was maintained uneventfully for about 7 h with target-controlled infusion (TCI) of propofol and remifentanil, except for a seizure generated when the right anterior central gyrus was stimulated to allow motor evoked potential monitoring. Immediately after the cessation of TCI, spontaneous respiration was restored. However, the patient was unexpectedly comatose, and no response to painful stimuli or coughing during

tracheal suctioning was observed. A computed tomogram taken 2 h after surgery showed diffuse brain edema, even though the neurosurgeons did not notice any cerebral swelling during closing of the dura mater. A magnetic resonance venogram revealed thromboses in the superior sagittal MRT67307 purchase and straight sinuses. On the 9th postoperative day, the patient died

without recovering consciousness or his brainstem reflexes. Anesthesiologists should be aware of CVST as a cause of delayed emergence from anesthesia after craniotomy.”
“Mass spectrometry (MS) is one of the key analytical techniques to detect and to identify primary sequence differences, to assess similarity and to evaluate batch variability of reference monoclonal antibodies (mAbs). The next generation of high-resolution mass spectrometers and the early use of improved MS-based methodologies will help bring biosimilar mAbs and Fc-fusion proteins into highly regulated markets. (C) 2013 Elsevier Ltd. All rights reserved.”
“Aim To report the debate on the relationship between overactive bladder (OAB) in children and adults during the ICI-RS meeting in 2010. Methods: Literature supporting or being against the theory that OAB in children and adults represents the same condition has

been reviewed and debated. Results: Growing evidence is showing a strong link selleckchem between urinary symptoms in childhood, such as nocturnal enuresis (NE) and OAB symptoms, and OAB in adulthood. Behavioral and environmental factors may have an important role in predisposed subjects. Studies on familial and genetic factors have been reported. Conclusion: It might be inappropriate to state that OAB in children and adults represents the same condition. However, epidemiological and genetic findings demonstrate a strong link between OAB symptoms in these two different ages of life. Predisposing factors and behavioral and/or environmental elements may lead to OAB occurrence in adults. Neurourol. Urodynam. 31:349-351, 2012. (C) 2012 Wiley Periodicals, Inc.”
“Modified and unmodified carbon fiber supports were treated with solutions of a polymer-gentamicin complex, possessing high antimicrobial activity and low toxicity. It was found that the antimicrobial activity of modified carbon fiber fabrics depended on the nature of the support and on the immobilization conditions.