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“Background and aims: It is unclear whether infliximab treatment induces increased complication rates after surgery for ulcerative colitis. Aim was to compare complication rates after pouch surgery in refractory ulcerative colitis patients

with versus without previous infliximab therapy.

Methods: We performed a retrospective study evaluating all patients who underwent an ileoanal J-pouch for refractory ulcerative colitis over a four-year period. Postoperative complications, infliximab use and time between last infliximab administration and restorative surgery were assessed. 1-stage procedures (proctocolectomy with pouch, with or without temporary diversion) and 2-stage procedures (emergency colectomy and subsequent completion proctectomy with pouch, with or without temporary diversion) were analyzed separately.

Results: Seventy-two INCB28060 cost patients were included; 33 underwent 1-stage procedure and 39 had 2-stage surgery. In the 1-stage group, 21 patients (64%) had previous infliximab therapy (median time between last infusion and surgery: 7.1 months (IQR 2.6-8.3)). Infliximab-treated

patients had higher incidence of pelvic sepsis (5/21 vs. 0/12; risk difference 24%; 95% Cl: 6 to 42, p=0.067) and non-infectious complications (8/21 vs. 1/12; risk difference 30%; 95% Cl: 4 to 56, p=0.065). In the 2-stage group, 17 (44%) had previous infliximab therapy (median time between last infusion and surgery: 11.8 months (IQR 7.3-15.5)). Total, infectious, non-infectious complication rates and pelvic sepsis rates were similar for infliximab and non-infliximab patients in the 2-stage group.

Conclusions: This small study suggests that infliximab use prior to 1-stage

restorative proctocolectomy in patients with UC is associated with increased incidence of pelvic sepsis. A 2-stage procedure in these patients should be considered. (C) 2012 Published by Elsevier B.V. on behalf of European Crohn’s and Colitis Organisation.”
“Introduction and objectives. The aim of this study was to determine the accuracy of self-reported diabetes, hypertension and hypedipidemia in a representative sample of adults (719 men and 837 women) from the south Stem Cells & Wnt inhibitor of Spain.

Methods. Self-reported data were gathered using a structured questionnaire. Biometric data recorded included blood glucose, total cholesterol and triglyceride concentrations and arterial systolic and diastolic blood pressures. The sensitivity, specificity, and positive and negative predictive values of self-reported diagnoses were calculated using the biometric data as the reference standard. The degree of overall agreement was determined using Cohen’s kappa coefficient.

Results. The kappa values obtained indicated good agreement for self-reported diabetes (kappa=0.78), moderate agreement for hypertension (kappa=0.51), and minimal agreement for hyperlipidemia (kappa=0.27).