03) and pre-Fontan mean right atrial pressure (P=.04).
Conclusions: At autopsy, hepatic fibrosis was commonly observed in patients who had undergone the Fontan operation. Portal fibrosis has been previously unrecognized in this population. Significant portal fibrosis occurred in most who died soon after the Fontan procedure and was associated with pre-Fontan morbidity. Hepatic disease in the single-ventricle population is multifactorial and may begin before the Fontan operation. (J Thorac Cardiovasc Surg 2012; 143: 904-9)”
“We previously found that the intronic
norepinephrine transporter gene (SLC6A2) polymorphism rs36017 modulates feelings of elation after administration of 20 mg d-amphetamine in healthy volunteers.
In this study, we further investigated the association between d-amphetamine response selleck products and 11 SLC6A2 single-nucleotide polymorphisms (SNPs), including rs36017,
in an extended sample of Caucasian young adults.
One hundred fifty-nine healthy volunteers participated in a three-session double-blind crossover design receiving either placebo or oral d-amphetamine (10 and 20 mg). Based on our previous results, we examined the associations between levels of self-reported elation and vigor after d-amphetamine administration and SNPs and SNP haplotypes in SLC6A2.
Consistent with our previous findings, SNPs rs36017 and rs1861647 were associated with significantly higher ratings of elation and vigor after 20 mg d-amphetamine. see more Ratings of vigor after 20 mg d-amphetamine were also associated with a two-SNP haplotype formed with rs1861647 and rs5569 and a three-SNP haplotype formed with rs36017, rs10521329, and rs3785155.
These results provide further evidence that genetic variants in the SLC6A2 gene are involved in acute response to d-amphetamine, which may influence progression to amphetamine abuse. Identifying sources of variation in acute drug responses could lead to better prevention and treatment of psychostimulant abuse and may be valuable in the therapeutic Celecoxib use of stimulants.”
“In a previous study (Simmons-Stern, Budson & Ally, 2010), we found that patients with Alzheimer’s
disease (AD) better recognized visually presented lyrics when the lyrics were also sung rather than spoken at encoding. The present study sought to further investigate the effects of music on memory in patients with AD by making the content of the song lyrics relevant for the daily life of an older adult and by examining how musical encoding alters several different aspects of episodic memory. Patients with AD and healthy older adults studied visually presented novel song lyrics related to instrumental activities of daily living (IADL) that were accompanied by either a sung or a spoken recording. Overall, participants performed better on a memory test of general lyric content for lyrics that were studied sung as compared to spoken.