e., induced) activity, and (ii) for induced theta activity, the trial-averaged ERP waveform was first subtracted from each single trial data,

with the residual being transformed to the TF domain. The resultant single trial TF surfaces were then averaged across trials to produce a TF representation of the event-related nonphase-locked TF activity. With these methods, one evoked TF representation and one induced TF representation were produced for each electrode site for each subject. To confirm the non-stimulus-phase-locked Inhibitors,research,lifescience,medical nature of the induced theta activity, intertrial coherence (ITC), a measure of the extent to which phase locking occurs across trials, Inhibitors,research,lifescience,medical was also calculated for induced theta at each electrode for each subject. Based on visual inspection of the grand-averaged evoked and induced

TF representations, poststimulus TF regions of interest (TFROIs), encompassing the theta-frequency band, were selected. The TF power was averaged within each of these TFROIs. For induced activity, in addition to Inhibitors,research,lifescience,medical the poststimulus TFROI, a corresponding prestimulus TFROI was also selected, covering the same frequency range as the poststimulus TFROI, but with a time window occurring prior to target stimulus onset. This prestimulus TFROI was utilized as a reference for comparing event-related changes in poststimulus power, that is, ERS/event-related desynchronization, which was computed as the log ratio of the poststimulus power to the prestimulus power (see Andrew and Fein 2010b, for a more detailed description). To examine resting theta power, the resting EEG data were first Inhibitors,research,lifescience,medical corrected for ocular artifacts, then divided into 1024-msec half-overlapping epochs (i.e.,

the first 512 msec of each epoch Alisertib order overlapped with the last 512 msec of the preceding epoch). Epochs with EOG amplitude >75 μV were eliminated from further processing. Fourier transform-based spectral estimation, using Welch’s periodogram method, was then applied to each artifact-free epoch using a Hamming Inhibitors,research,lifescience,medical window, resulting in power spectra with 1-Hz resolution. The mean absolute power within the same theta-frequency range used in the evoked and induced TF analyses (3–6 Hz, see below) was then calculated for each electrode site. Because the distribution of Bay 11-7085 theta power was skewed, the data were log transformed. Statistical analysis All statistical analyses were performed using SPSS (SPSS Inc., Chicago, IL). The measures submitted to statistical analysis were (1) evoked theta power (log-transformed) averaged over electrodes Pz and CPz and (2) induced theta activity (theta ERS) averaged over electrodes FCz and Cz. These electrodes were those within which each of the measures was found to be maximal, both in the current study and in previous reports (e.g., Jones et al.