NERD; Presenting Author: DEREKJAH-YUEN LUO Additional Authors: HSIANGC JOHN Corresponding Author: DEREKJAH-YUEN LUO Affiliations: Counties Manukau DHB; Counties Manukau District Health Board Objective: AimTo examine the frequency of HLA DQ2.5/DQ8 alleles among different ethnic

groups from HLA tissue typing cohortBackgroundAbout 90% of individuals with coeliac disease carry the HLA DQ2.5 gene and practically all the remaining patients express HLA DQ8. Clinically Coeliac disease seems rare among non-Europeans. Methods: MethodRetrospective review of 391 HLA DQ2.5/DQ8 tissue typing samples from NZ BVD-523 Blood Service. The demographic details are obtained from the NZ Health Information Services. HLA DQ2.5, DQ8 frequencies were examined. (HLA DQ2.5 DQA1*0501; DQB1*0201), DQ8 (DQA1*0301; DQB1*0302)) Results: ResultOf the 391 samples;

European (44.8%), Maori (40.7%), Pacific Island (6.9%), and Asian (5.4%). 43% of the samples were from bone marrow typing, 12.3% from lung transplant donor/recipient. HLA DQ2.5 homozygosity was present in 2.29% European, and absent in Maori, Pacific Island or Asian groups. DQ2.5 heterozygosity was present in 1.71% European, 1.3% Maori, absent in Asian and Pacific Island groups. HLA DQ8 homozygosity was present in 1.14% of European, 1.9% Maori, absent in Asian or Pacific island groups. DQ8 heterozygosity was present in 2% European, 5% Maori, 7.4% Pacific Island, and absent in Asian. The overall AZD6738 mouse DQ2.5 allele frequencies were 4% (European) and 1.85% (non-European), and DQ8 allele frequencies were 3.14% (European) and 6.94% (non-European). Conclusion: ConclusionHLA MCE DQ2.5 homozygosity was more common in the European (p < 0.01) and HLA DQ8 homozygosity was more common in Maori (p < 0.01), compared to other ethnic groups. The HLA allele frequencies do not explain the current low prevalence of Coeliac disease among non-Europeans. Dietary, environmental factors may be of greater importance. Word count: 250 words. Key Word(s): 1. HLA DQ2/8; 2. Coeliac Disease; 3. Ethnic differences; Presenting Author: NOUFKHALID HAMID Additional Authors: NAWAF ZAKARY Corresponding Author: NOUFKHALID HAMID Affiliations: King Fahd Military Medical

Complex; King Fahd Military Medical Complex Objective: Bezoars in general are rare, being found in less than 1 percent of patients undergoing upper gastrointestinal endoscopy [1]. The types of bezoars depends on their content, Trichobezoar is one of them which is a gastric hair mass that can results from trichotillomania or trachophagia. In this report we will represents two cases of young females with trichobezoar that results from trichophagia and their management. There are several management options for removal of the bezoar in the form of endoscopy, laparoscopy, and laparotomy in both cases endoscopy was first initial line of intervention for thier removal, but it failed in both patients due to the large size of bezoar, then laparotomy was done.